This research explores a framework of selecting suitable industry cooperation ares between South Korea and North Korea using analysis of science and technology(S&T) competitiveness. First, a generic framework to set up S&T cooperation with North Korea, which involves both a continuity as an evolving process and a peculiarity of S&T, is presented. Second, a selection procedure of specific S&T areas for South and North cooperation is suggested. It is also demonstrated how to select suitable S&T cooperation areas under two types of scenarios. Finally, promotion strategies for each scenario are described.