The objective of this paper is to develop defect assessment technology for integrity evaluation of CANDU pressure tubes. In fracture mechanics analysis, three-dimensional and two-dimensional (line-spring model) finite element analyses were performed to obtain the stress intensity factor for axial and circumferential surface cracks. In leak before break (LBB) analysis, heat transfer analyses for through-wall cracks were performed by considering the cooling effect and the LBB application time was computed. It was shown that the analytical results obtained in this study provide less-conservative but accurate solution for defect assessment of CANDU pressure tubes.