A high-precision pre-amplifier is designed for general use in EEG measurement system. It consists of signal generator, signal amplifier with a impedance converter, shield driver, body driver, differential amplifier, and isolation amplifier. The combination of minimum use of inaccurate passive components and the appropriate matching of each monolithic amplifiers results in good noise behavior, low leakage current, high CMRR, high input impedance, and high IMRR. The performance of EEG pre-amplifier has been verified by showing the typical EEG pattevn of a nomad person through the clinical experiments.