The scavenging characteristics have a great influence on the performance of a diesel engine, especially slow-speed two-stroke diesel engines which are usually used as a marine propulsion power plant, and they are greatly affected by the conditions in the cylinder, intake and exhaust manifolds, and the opening and closing timing of scavenging ports or exhaust valves during the gas exchange process. Besides, there are many other factors to affect the scavenging characteristics and these factors interact each other very complicatedly. Therefore the simulation program of the gas exchange process is very useful to improve and predict the scavenging characteristics, due to the high costs associated with redesign and testing. In this paper it was attenpted to investigate the effect of the variation of the pressure ratio of intake to exhaust manifolds, and the variation of the opening and closing timing of a exhaust valve by using a computational program for a three-zone scavenging model which was developed by authors. The computed results showed that the scavenging efficiency and delivery ratio increased considerably, but the trapping efficiency decreased with increasing of the pressure ratio of intake to exhaust manifolds. The scavenging efficiency, trapping efficiency, and th conditions of the cylinder gases were affected by the opening timing of the exhaust valve, but the delivery ratio by the closing timing.