QUAL2E model is applied to predict T-N and T-P concentrations in the downstream of the Han River. Sensitivity analysis shows that the pertinent parameters for T-N and T-P have small effects on the computed concentrations. The computed concentration profiles of T-N and T-P show good agreements with recently measured data. The future tributary loads of T-N and T-P have been estimated to simulate concentrations. The modeling result has been presented under the mean and low flow condition after wastewater treatment in the future.