Mathematical models have been developed in which storage-relaease processes of pollutants are modeled to explain storage effect of variations of flow and channel geometry on mixing and transport of polluted releases in natural channels including low flow conditions. The models were tested by using the laboratory dispersion data. Comparisons between concentration-time curves predicted by using the proposed model incorporating two different submodels show that Storage-Diffusion Model seems to be superior in explaining physical processes inside the storage zone to the Storage-Exchange Model even though accuracies of simulation results by two models are about the same. The proposed model shows significant improvement over the conventional one-dimensional dispersion model in predicting natural mixing processes in open channels.