The final aim of our research project is a study on assessment of automatic steering system of ships in open seas. In order to achieve this aim, we need to know the characteristics of each component of the system, and also to know the characteristics of disturbance to ship dynamics. In this paper, we provide calculation method of irregular disturbance to ships in autopilot navigation in open seas, and also show calculation examples about two kinds of ship, ore carrier and fishing boat. The disturbance consists of irregular wave and random wind. The disturbance is calculated as equivalent yaw angular velocity. Each spectrum and time history of disturbance are reasonably evaluated. Further investigation concerning to performance index of autopilot system and energy loss related to automatic course keeping, will be dealt with in another paper.