The effect of loading variables and temperature on fatigue crack growth rate in SA508 Cl.3 nuclear pressure vessel steel was investigated in air environment Crack growth rate tests on compact tension specimen of thickness 12mm were conducted by using sinusoidal waveform. The crack length was monitored by compliance method. Test conditions were at 0.1 and 0.5 of load ratio, at 1 and 10 Hz of loading frequency, and at room temperature to 40$0^{circ}C$. At the lower temperatures, the fatigue crack propagation was not affected by the frequency and temperature, while at the higher temperatures above 12$0^{circ}C$, fatigue crack growth rate increased with decreasing loading frequency and increasing temperature. This accelerated fatigue crack propagation was associated with the increase of oxidation rate at the ahead of crack tip. Fatigue crack growth rate increased with in-creasing the load ratio. The effect of load ratio was more significant at the lower temperature, while the dependence on load ratio decreased with increasing temperature. The sensitivity of load ratio to temperature can be explained by crack closure with the oxidation process.