It is essential in evaluating the chronic pain patients that the physician obtain a multiple causative factors including organic, psychological, and socioenvironmental factors. Though these multiple factors are involved in the development of chronic pain syndrome, chronic pain syndrome is not only the sum of the interaction of all of these factors, but is also influenced by the sequelae of chronic pain, which again are organic, psychological, and socioenvironmental in nature. Therefore a systemic approach is probably the best way to asses the role of all of these factors. Furthermore, this approach can provide a framework for understanding chronic pain syndrome, for assessing chronic pain syndrome, for the rational management of chronic pain syndrome, and for the development and testing of hypotheses.