Psoas compartment block has been used to provide anesthesia for orthopedic surgical procedures and postoperative pain control. Nowadays this block is advocated for the management of pain in the thighs, legs and lumbar area for various reasons. To relieve pain in the thigh and leg, 21 times of block were performed and observed clinically in the 17 patients at our hospital. The results were excellent for the relief of pain in metastatic cancer patients. And this block is satisfactory in the thigh pain but not in the leg pain. So we recommend psoas compartment block as a useful and simple method for the relief of pain in metastatic cancer pain in the thigh.