Poly(ethylene glycol)(PEG) macromers terminated with diacrylate Iyoups and interpenetrating poly- mer networks(IPN) composed of poly(hydroxyethyl methacrylate)(PHEMA) or poly(hydroxyethyl methacrylate-co-hydronypropyl methacrylate-co- N-vinyl pyrrolidone ) [ P( HEM A-co- HPM A-co- NVP) ] and PEG macromer were synthesized with the aim of obtaining protein adsorption resistant soft contact lens. Polymerization of PEC macromer resulted in the formation of cross-linked gels due to the multifunctionality of macromer. Crosslinked P(HEMA) or P(HEMA-co-HPMA-co-WVP) chains were interpenetrated into the cross-linked three-dimensional networks of PEG. It was found that albumin adsorption onto the contact lens prepared by P(HEMA-co-HPMA-co-NVP) /PEG IPW decreases with an increase of molecular weight of PEG. Also, it was found that albumin adsorption onto the both contact lens decreases with an increase of concentration of PEC macromer in the IPN preparation. There are also more adequate in the bioinertnen for the contact lens by P(HEMA)/PEG IPN or P (HEMA-co-HPMA-co-NVP)/PEG IPN than that by P(HEMA) or P(HEMA-co-HPMA-co-NVP)