We presetn sytem-level simulation methodology as well as environment setup established for CDMA digtial cellular mobile station in an effort to verify CDMA modem ASIC design. To make the system-level simulation feasible, behavioral modeling of a microcontroller was first carried out with VHDL. In addition, models written in C language were also developed to provide ASIC with realistic input data. Finally, the netlist of CDMA modem ASIC was loaded on the a hardware accelerator, which was interfaced with VHDL simulator, and ismulation was performed by excuting the actual CDMA call processing software. Simulation resutls thus obtained were confirmed by comparing them with the emulation resutls from the actual system constructed on hardware modeler. these methods were proved to be effective in both discovering in advance malfunctions when embedded in the system or design errors of ASIC and reducing simulation time by a factor of as much as 20 in case of simulation at gate-level.