The active noise cancellation system showing the effective convergence and stability has been studied by simplifying the controller structures using the weighting factors of control error path to the multi-channel filtered-x LMS algorithm which needs a lot of calculations and the performance has been verified experimentally. Besides, to implement the system performance in a vehicle cabin, experimental work for selecting the suitable numbers and positions of the microphones and speakers was accomplished. Effectively combining a TMS 320C 31 main processor conducting real number calculations and having various functions with other components, the purpose-built system board for active noise cancellation has been designed and with this board, car active noise cancellation system showing maximum stable 10dB noise reduction has been obtained at the car idling conditions above 3000rpm range.