Natural gas is one of the promising alternative fuels for automotive vehicles, because it has lower exhaust emissions and better fuel economy characteristics than those of gasoline, and can be used in conventional gasoline engines without major modifications. In the present study, a conventional gasoline engine was modified to a CNG engine, which can be operated with CNG only, and an engine bench test was performed to calibrate the operating parameters of the engine such as air fuel ratio, spark advance, etc. at various operating conditions. The modified CNG engine, then, was installed on a commercial gasoline vehicle and a vehicle driving test on chassis dynamometer was performed to examine the fuel economy and exhaust emission characteristics. As a result, the prototype CNG vehicle showed lower exhaust emissions and better fuel economy characteristics, but slightly reduced brake horse power, compared to the gasoline vehicle.