Early orthodontic treatment in growing children requires the removable orthodontic appliances. The removable orthodontic appliance can be used in the primary dentition and mixed dentition. The purposes of use of removable orthodontic appliance in prmary dentition or mixed dentition are the interception of skeletal or dental malocclusion, guiding the normal dentition, and retention after comprehensive orthodontic treatment. Therefore, it is needed to use the removable orthodontic appliance in children with malocclusion. This report presents cases of growing children with skeletal class II and III malocclusion treated with removable orthodontic appliance during mixed dentition and Multiloop Edgewise Arch Wire(MEAW) during permanent dentition. The results obtained through these cases were summarized as follows : 1. Removable orthodontic appliances guide normal dentition and skeletal growth in growing children. 2. Removable orthodontic appliances play an important role in intercepting malocclusion in mixed dentition before use of fixed orthodontic appliance. 3. MEAW can be applied to finishing stage of all cases and is effective in correction of occlusal plane, achievement of interdigitation, and control of dental inclination. 4. It is needed that removable appliances are used during mixed dentition through correct diagnosis and fixed appliance are used in permanent dentition.