An Experimental study were done to examine the clinical effects of Mokwhyangbinrang-Whan on gastrointestinal disease and undertakened by being carried out with rat. We work on the digestive system of Mokwhangbinrng whan. The following results have been obtained ; 1. Spontaneous mobilities in the isolated ilem wewe significantly suppressed and relaxative effects in the isolated ileum were recognized. 2. Significant preventure effects wewe recognized on the pylorus - lighted ulcer in rat(p<0.01) 3. Remarkable preventure effects were recognized on the indomethacin induced gastric ulcer(p<0.01) 4. Inhibitory effects on gastric juice was recognized(p<0.01). Inhibitory effects of free & total acidity were recognized(p<0.05). 5. Significantic analegegic effects were recognized by acetic acid in Mice(p<0.01). 6. Duration of Hypnosis induced by penthbarbital-Na was significantly prolonged (p<0.01). 7. Anti-convulsion action of fat induced by picrotoxin & caffeine was recognized (p<0.05). Notable preventure effects were revealed on the strychnine induced convulsion in rat(p<0.01). According to the above experimental results, it can be conclude that effects of references and clinical application of Mokwhyangbinrng-Whan are approximate.