It has been used that fluorinated compounds could be applied to cosmetic products. It is that fluorinated conpounds are hydrophobicity and lipophobicity. These fluorinated compounds are reported to form a highly protective and effective film against most aggressive chemical and physical agents. PerfluropolymethyoisopropylEther has homophobicity and are colorless, odorless, tasteless and non-greasy. In this we made a success to formulate the new type of hand care cream using PFPE. PFPE are suitable thickness and chemical inertness to skin. The reason that we select PFPE for this investigation. We developed the new type hand care cream by adsorption and dispersion of PFPE. There are very stable dispersion and highly moisture diffusion control. And these characteristics were verified by actual consumer test.