The purpose of this paper is to design cutter profiles for manufacturing rotors of screw compressor, which are based on universal milling machine. The surface profile of screw rotor which is helicoidal is derived as brief equation through the coordinates transformation of the section perpendicular to rotor axis. And the equations of contact lines between a cutter and the surface profile of screw rotor are derived. The computer program which can analyze the equation of contact lines numerically and design the cutter profiles of screw rotor is made, and verified through measuring screw rotors which are menufactured as the designed cutter by the computer program.