This paper considers to determine the processing workstation of parts and number of machines at workstations in multi-stage manufacturing system. Several part types are processed simultaneously through multi-stage, which consist of several workstations. The machines in each stage are identical in function, but non-identical in functional performance depending on workstations. Two models are suggested. One is assumed that a part type can be processed at the only one workstation in each processing stage. The other is assumed that a part type can be processed at several workstations. Decision criteria is to minimize the sum of the processing cost, travel cost and machine setup cost. Model formulations are presented, and a numerical example is shown.