In order to improve the safety of nuclear power plant, we performed a human factors review for the CFMS(Critical Function Monitoring system) design of nuclear power plant. Three works were performed in this study. In first work, we developed human factors engineering program plan(HFEPP) and human factors engineering verification and validation plan (HFE-V & V plan) to effectively perform CFMS design and review. In second work, we identified human engineering discrepancies(HEDs) for CFMS design through human factors design review and proposed those resolutions. In the third work, we developed the evaluation and management methodology for identified KEDs. Methodology developed in this study can be used in other complex system as well as in CFMS design review.