- 1N-아릴-2-메틸-3-에톡시카르보닐-피리디노 [2,3-f]인돌-4,9-디온 유도체의 합성 (II)
- ㆍ 저자명
- 서명은,박희경,Suh. Myung-Eun,Park. Hee-Kyung
- ㆍ 간행물명
- 약학회지
- ㆍ 권/호정보
- 1997년|41권 5호|pp.582-587 (6 pages)
- ㆍ 발행정보
- 대한약학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
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The 6.7-dichloroquinoline-5,8-dione (I) was reacted with ethyl acetoacetate in the presence of sodium ethoxide to yield 6-(${alpha}$-acetyl-${alpha}$-ethoxycarbonyl methyl)-7-chloro-qui noline-5,8-dione(II). When this compound II was reacted with some arylamine (phenyl, p-toluyl, p-fluorophenyl, p-chlorophenyl. p-bromophenyl, p-iodophenyl, p-trifluoromethylphenyl, p-dimethylaminophenyl,indanyl), 1N-aryl-2-methyl-3-ethoxycarbonyl pyridino[2,3-f]-indole-4.9-dione(IIIa-I) were obtained via intramolecular cyclization.
67-dichloroquinoline-58-dione6-(${alpha}$-acetyl-${alpha}$-ethoxycarbony1 methyl)-7-chloro-quinoline-58-dione1N-pheny1-2-methyl-3-ethoxycarbonyl pyridino[23-f]indole-49-dione1N-p-dimethylaminophenyl-2-methyl-3-ethoxycarbonyl pyridino[23-f]]indole-49-dione1N-p-fluoro-phenyl-2-methyl-3-ethoxycarbonyl pyridino[23-f]indole-49-dione