Chronic fatigue syndrome Is a syndrome of unknown etiology and pathophysiology characterized by severe, chronic, debilitating fatigue as main symptom and numerous additional symptoms such as joint and muscle pain, headache, sleep disturbance. According to recent researches, it was suggested that chronic fatigue syndrome was developed by disturbance of interaction between neuropsychiatric system and immune system due to environmental factors and stress. Many patients experience gradual improvement but complete recovery from disorderd state is rare. There was no research elucidating the exact pathogenetic mechanism of chronic fatigue syndrome, so there was no established treatment. Several controlled studies about treatment was reported, but its results was not effective in all patients with chronic fatigue syndrome. For chronic fatigue syndrome, a comprehensive approach to physical, psychological, and social aspects is needed.