The bogie between the track and the railway vehicle body, is one of the most important component in railroad vehicle. Its effects on the safety of both passengers and vehicle itself, and on the overall performance of the vehicle such as riding quality, noise and vibration are critical. The bogie is mainly consisted of the bogie frame, suspensions, wheels and axles, braking system, and transmission system. The complex shapes of the bogie frame and the complicate loading condition (both static and dynamic) induced in real operation make it difficult to design the bogie frame fulfilling all the requirements. The complicated loads applied to the bogie frame are i) static load due to the weight of the vehicle and passengers, ii) quasi-static load due to the rolling in curves iii) dynamic load due to the relative motion between the track, bogie, and vehicle body. In designing the real bogie frame, fatigue analysis based on the above complicated loading conditions is a must. In this study, stress analysis of the bogie frame has been performed for the various loading conditions according to the UIC Code 6 15-4. Magnitudes of the stress amplitude and mean stress were estimated based on the stress analysis results to simulate the operating loads encountered in service. Fatigue strength of the bogie frame was evaluated by using the constant life diagram of the material. 3-D surface modelling, finite element meshing, and finite element analysis were performed by Pro-Engineer, MSC/PATRAN, and MSC/NASTRAN, respectively.