Purpose : This study was performed to design a safe air-pressure reduction system which can absorb rapidly rising intraluminal pressure during intussusception, and comparison with other reduction systems to test its clinical availability. Materials and Methods : The air-pressure reduction system consisted of a pressure gauge, air insufflators, a pressure controller, buffers, and rapid exhaustion devices, and to determine its absorbability, it was connected with a bowel model. By using it in 20 infants with intussusception, we compared the absorbability of our air-pressure reduction system with preexisting systems.Results : While extraluminal pressure was applied to the bowel model in which baseline intraluminal pressure was set to 120mmHg, this rose to176mmHg (56mmHg high to standard, 100%) in the direct infusion system, but to only 130 mmHg (10mmHg high to standard, 17.9%) in a system connected to a large buffer of 10,500mL capacity. Immediately after the application of extraluminal pressure for less than 1 sec, this air-pressure reduction system showed better absorbability than the hydrostatic reduction system. Applying this system to 20 infants with intussusception, this was successfully reduced in 19 cases(95%), without complications.Conclusion : In this experiment, it was proved that the system absorbed rapid intraluminal pressure elevation. Its use would help prevent bowel perforation during air reduction occurring during intussusception.