Various equipments in plants are welded with two different materials and it is required to investigate the effects of fatigue crack propagation on the neighborhood of a welded portion. The characteristics of fatigue crack growth in the base metal of carbon and stainless steel, in the carbon and stainless steel sides located in the neighborhood of welded portion (carbon/stainless steel), respectively and welded portion, are investigated. The results show that the crack growth in the welded portion (carbon/stainless steel) is an average value of the crack growths in the carbon and stainless steel respectively located in the neighborhood of the welded portion. It is found that the crack growth in the welded portion is not significantly different from those in the carbon and stainless steel sides. Hence it can be concluded that the structure welded with two different materials wold not impede the integrity based on the fatigue crack growth.