This paper presents the physiological signal processing CMOS one chip for transmitting human bodys small electrical signals such as electrocardiogram(EKG) or electromyogram(EMG) and the external system for receiving signals was implemented by the commercial ICs. For simultaneous four-subject four-channel telemetry, a new enfored synchronization techniqeu using infrared bi-directional communication has been proposed. The telemeter IC with the size of 5.1*5.1mm$^{2}$ has the following functions: receiving of command signal, initialization of internal state of all functional blocks, decoding of subject-selection signal, time multiplexing of 4-channel modulated physiological signals, transmitting of telemetry signal to external system and auto power down control. The newly designed synchronized oscillator with low supply voltage dependence in the telemeter IC operates at a supply voltage from 4.6~6.0V and the nonlinearity error of PIM modulator was less than 1.2%F.S(full scale). The power saving block operates at the period of 2.5ms even if the telemetry IC does not receive command signal from external system for a constant time.