Incidence of gastrointestinal disease in dogs of Seoul and Kyung-gi area was 40.5% (380/939) and dogs with gastrointestinal disease were more likely to be 1-5 month old (55.5%). Comparison among seasons revealed that spring(48.3%) was potentially at increased risk The incidence of pancreatitis in the gastrointestinal disease was 1.49% (6/402). In helathy dogs, amylase activity was higher in male dogs than female and in the alee of >1 year than <1 year. Lipase activity was higher in female dogs than male, and higher in the age of <1 year than >1 year. The correlation coefficient$(r^{2})$ was 0.71 between the methods of measuring amylase; amyloclastic and chromogenic methods.