A dynamic fluid-structure-soil interaction analysis method is developed to investigate the effects of translational and/or rocking motions on the seismic response of flexible rectangular liquid storage tanks founded on the deformable ground. The governing equation for the dynamics of 3-D rectangular tanks subjected to the translational and/or rocking motion is abtained by applying Rayleigh-Ritz method. The dynamic stiffness matrices of a rigid rectangular foundation resting on the surface of a stratum overlaid bedrock are calculated by hyperelement method. The seismic responses of 3-D flexible tank model founded on the deformable ground is calculated by combining the governing equation for the fluid-tank system with the dynamic stiffness matrix of th rigid surface foundation.