In view of the rapid development of economics and technology, perilous meteorological and geological conditions often cause natural disasters and result in severe loss of lives and properties in Taiwan. To promote multi-hazard mitigation strategies in an integrated a, pp.oach, the National Science Council established a National Science and Technology Program for Disaster Mitigation in January 1998. This program emphasizes on the implementation of research results in the National Disaster Management System. This paper describes the earthquake loss estimation methodology that is currently developed in Taiwan. Topics of potential earth science hazards (PESH) and building vulnerability analysis are described in detail.