Seom River was major branch of Namhan river, consist of primary basin that Wonjoo-city, Hoingsung-gun and primary contamination source was sewage from human lives. This study was evaluated production contamination loading of each branch basin and water quality grade and water quality simulation by QUAL2E to provide efficient contaminations source control. Rusult of survey, production loading of BOD, T-N, T-P were 26,591 kg/day, 4,560 kg/day, 731 kg/day resectively. Water quality analysis in 17 points of main stream were appeared that 1st grade(BOD 1 mg/l under) was 6 point, 2nd grade was 9 point and 3rd grade was 2 point. And result of water quality analysis for branch steram, first grade was evaluated 68.7%. Based of field data, calibration and verification result were in good agreement with mesured value within coefficient of variance were from 2.59% to 18.73%, from 6.39%, to 28.46%, respectively.