This study was designed to identify the relationship between perceived pain, family support and quality of life in patients with ankylosing spondylitis. The purpose of this study was to contribute to the theoretical understanding of the relationship of these three variables and eventually to more effective adaptation of patients to their situation. The subjects for this study were the 68 patients who had been diagnosed with ankylosing spondylitis and registered as out-patients in the Rheumatism Center of one university hospital in Seoul. The data were collected during the period from October 10, 1997 to December 20, 1997, Pain was measured using the perceived pain scale(VAS : Visual Analog Scale)developed by Calm(1993), family support using the scale developed by Kang Hyun Suk (1985) and Quality of Life using the scale developed by Ro Yoo Ja(1988). The data were analyzed by descriptive statistics, Frequencies, Pearson correlation coefficient, using the SPSS program. The results of this can be summarized as followings. 1. The mean perceived pain score was 5. 13 with a range of 2 to 10. 2. The mean perceived family support score was 41.08$pm$5.34 with a range of 20 to 50. 3. The mean perceived quality of life score was 134.07$pm$19.82 with a range of 83 to 176. 4. Significant statistical difference was found between family support and quality of life (r=.331, p<0.001). A significant negative statistical difference was found between the family support and quality of life and pain(r=-.250, p<0.05, r=-.460, p<0.001). 5. General characteristics related to pain were exercise (t=4.72, p<0.0006). 6. General characteristics related to family support were age(F=2.65, p<0.0246), educational level (F=2.84, p<0.0282) and exercise (t=3.24, p<0.0452). 7. General characteristics related to quality of life were educational level (F=3.03, p<0.0392) and exercise (t=3.12, p<0.0465). It was found that the higher the level perceived pain, the lower the degree of perceived family support and the quality of life. It was also found that the higher the degree of perceived family support, the higher the degree of perceived quality of life. Accordingly, the conclusions from this study are that reduction of pain is achieved through the family support. Therefore, it is proposed that family support is an appropriate nursing intervention to improve the quality of life of patients with ankylosing spondylitis.