This paper presents an autopilot design method for STT missiles using the intelligent control technique and multiple controllers. The mixed $H_2/H_{infty}$ control technique is applied for each controller design and the control gains are implemented by using the genetic searching algorithm. To facilitate automatic switching of multiple controllers under different operating conditions, an error based switching scheme is also combined with the multiple controllers at a higher level, which constitutes a hierarchical intelligent control system. It is shown via computer simulation that the proposed autopilot outperforms the conventional one.