Chondrosarcoma of bone commonly involve the pelvis, femur and shoulder girdle but the hyoid bone is a rare site for primary chondrosarcoma with approximately 10 cases having been reported in the literature. Radiologically it was well marginated and radiolucent mass with medullary bone destruction and central calcification. Wide surgical excision with or without radiotherapy is genera31y regarded as the treatment of choice for chondrosarcoma. Histopathology of chondrosarcoma was classified to clear cell chondrosarcoma, mucinous chondrosarcoma, dedifferentiated chondrosarcoma, and mesenchymal chondrosarcoma. We report a case of chondrosarcoma that originated from the right greater cornu of the hyoid bone, which underwent excision of the tumor with hemihyoidectomy and postoperative radiotherapy was performed.