A procedure of stress and strength analysis has been proposed for the centrifuge rotor of composite materials of quasi-isotropic laminates. The goal in this study is to maximize the allowable rotating speed, that is, to minimize maximum strength ratio with the given path length by changing the geometric parameter-outer radius and ply angles in quasi-isotropic laminates. Optimum values of the geometric parameter-outer radius and ply angles are obtained by multilevel optimization. All the geometric dimensions and stresses are normalized such that the result can be extended to a general case. Two dimensional analysis at each cross section with an elliptic tube hole subjected to internal hydrostatic pressures by samples as well as the centrifugal body forces has been performed along the height to calculate the stress distribution with the plane stress assumption, and Tsai-Wu failure criterion is used to calculate the strength ratio. The maximum allowable rotating speed can be increased by changing the radii of the outer surface along the height with the maximum strength ratio under the unit value : The optimal number of ply angles maximizing the allowable rotating speed in quasi-isotropic laminates is found to be the half number of tube hole, and the optimal laminate rotation angle is the half of $[{pi}/m]$. A $[{pi}/3]$ laminate, for instance, is stronger than a $[{pi}/4]$ laminate for the centrifuge rotor of 6 tube hole number even though they have the same stiffness.