식이성 고지혈증 유발 Sprague Dawley계 숫흰쥐를 사용하여 용담 열수 추출액을 급여하므로써 혈당 및 혈청의 지질 개선 효과를 규명하기 위해 4주간 실험 사육한 결과, 혈당 농도는 대조군인 1군(물)에 비해 2군(콜레스테롤+물) 및 3군(콜레스테롤+용담추출액)이 높게 나타났으며, 콜레스테롤과 용담 추출액을 급여한 3군이 2군(콜레스테롤+물)보다 다소 낮은 경향을 보였지만 혈당 저하효과는 유의성있게 관찰되지 않았다. 혈청중 총콜레스테롤 농도는 2군에 비하여 3군이 유의적으로 낮게 나타났다. LDL-콜레스테롤 농도는 2군에 비해 3군에서 유의성있게 감소하였으며, 총콜레스테롤에 대한 HDL-콜레스테롤 농도비는 용담 추출액 급여군이 높게 나타났다. 혈청 유리 콜레스테롤 및 콜레스테롤 에스테르 농도는 콜레스테롤 급여군인 2군에 비해 용담 추출액 급여군(3군)이 유의성 있게 감소하였다. 중성지질 및 인지질 농도는 3군의 농도가 낮았다. 혈청 AST 및 ALT활성은 대조군에 비하여 여타 실험군에서 증가하는 경향을 보였다. 이상의 결과에서, 용담 열수 추출액이 식이성 고지혈증 흰쥐에 대한 혈청지질 개선효과가 다소나마 있는 것으로 사료된다.
This study was designed to observe the effects of the feeding Gentiana scabra Bunge var.buergeri Max. extract on the improvement of the blood glucose, lipids in the serum of dietary hyperlipidemic rats (S.D. strain, ♂) fed the experimental diets for 4 weeks. Concentration of blood glucose was significantly higher in the cholesterol administration groups (group 2(cholesterol+water), 3(cholesterol+Gentiana scabra Bunge extract) than those in the control group(group 1 (water)). Blood glucose concentration was rather lower in the group 3(cholesterol+Gentiana scabra Bunge extract) than in the group 2(cholesterol+water). There was almost little significance among the groups. Concentration of total cholesterol in serum was significantly lower in the group 3 than those in the group 2. Concentration of LDL-cholesterol in serum was significantly lower in the group 3 than that in the group 2. In the ratio of HDL-cholesterol concentration to total cholesterol concentration, Gentiana scabra Bunge extract administration group was higher percentage than in the group 2. Concentration of free cholesterol and cholesteryl ester in serum was significantly lower in the group 3 than in the group 2. Concentrations of triglyceride and phospholipid in serum were decreased in the group 3 than in the high fat diet group. The activities of aspartate aminotransferase and alanine aminotransferase in serum were increased in the all experimental groups than in the control group. From the above research, the Gentiana scabra Bunge var.buergeri Max. exacts were effective on the improvement of the lipid composition in serum of dietary hyperlipidemic rats.
