Myasthenia gravis is a neuromuscular disorder that affects striated muscles especially those innervated by the cranial nerves. Most patients present with symptoms relating to the head and neck and thus may be seen first by the otolaryngologist. Recently we had experienced a case of myasthenia gravis with the complaints of hypernasality and voice fatigue in a 49 year old male. In this case, all symptoms were improved markedly with administration of anticholinesterase.