This paper is to evaluate the application potentials of data mining in the areas of Supply Chain Management (SCM) and to suggest the architectures of Decision Support Systems (DSS) that support data mining activities. We first briefly introduce data mining and review the recent literatures on SCM and then evaluate data mining applications to SCM in three aspects: marketing, operations management and information systems. By analyzing the cases about pricing models in distribution channels, demand forecasting and quality control, it is shown that artificial intelligence techniques such as artificial neural networks, case-based reasoning and expert systems, combined with traditional analysis models, effectively mine the useful knowledge from the large volume of SCM data. Agent-based information system is addressed as an important architecture that enables the pursuit of global optimization of SCM through communication and information sharing among supply chain constituents without loss of their characteristics and independence. We expect that the suggested architectures of intelligent DSS provide the basis in developing information systems for SCM to improve the quality of organizational decisions.