As a part of closed-loop guidance law studies for anti-ballistic missile defense, a mid-course guidance law is proposed to engage the target with the predetermined attitude for increased terminal effectiveness. The proposed guidance law is based on the predicted target position calculated from a simplified solution of target motion and the estimates of an extended Kalman filter utilizing noisy nonlinear radar measurements. Extension of the proposed mid-course guidance to 3 dimensional engagements are also studied. Performance of the proposed mid-course guidance law together with a terminal guidance law in the form of conventional proportional navigation guidance is evaluated by a series of simulation studies.