This paper uses the numerical simulation to investigate the interference effect of 3-D turbulent flow around two high rise buildings in proximity at the different relative heights, gaps, and wind velocities. The computer program used to carry out the simulation is based on the control volume method and the SIMPLEST algorithm. The ${kappa}-{varepsilon}$ model was used to simulate turbulence effects. Since the contracted flow between two adjacent buildings enhances the strength of vortex shedding from the object building, the pressure coefficient on each side wall of the object building is generally increased by the presence of apposed building. The effect is increased as the relative height or the gap between the two buildings decreases. The velocity on the vertical center line between two buildings is about 1.4 to 1.5 times the upstream wind velocity.