The purpose of this study was to evalute the effect of immersion disinfection on the dimensional stability of rubber impression materials. The metallic master model was made in order to simulate the intraoral arch form. Impressions were made from four impression materials (Exaflex, Extrude, Reprosil, Impregum-F) and immersed in three disinfectant solutions (Wydex, Vi-Pon, Potadine). Casts from the impressions were measured according to the interpreparation distance. The A-B and The B-D abutment distance were compared with the control group and disinfected groups. The results were as follows; 1. The measurements of the stone cast increased relative to the master model and there was a significant difference (P<0.05). 2. The relative dimensional change of the stone cast as compared with master model ranged from 0.10% to 0.56% in the A-B distance and ranged from 0.04% to 0.27% in the B-D distance. 3. The dimensional change of the disinfected groups as compared with the control group was significantly different in the three impression materials except for Impregum-F (P<0.05). 4. The relative dimensional change of the disinfected groups compared with the control group ranged from 0% to 0.20% in the A-B distance and ranged from -0.09% to 0.11% in the B-D distance. These results suggest that immersion disinfection of rubber impression materials by chemical disinfectants causes very small dimensional change and the change is clinically acceptable for prothesis fabrication