Toothash and Plaster of Paris(Calcium sulfate) mixture have been studied for development of new biomaterial since 1992. I have performed the experimental and clinical study for evaluation of biocompatibility and possibility of bony defect reconstruction and clinical application. These materials are biocompatible, osteoconductive and resorbable. Main component of toothash is hydroxylapatite. In the future, I will perform the systematic construction of material and additional research.