- 베타카로틴 함유 알긴산 나트륨 비드의 제조 및 안정성
- ㆍ 저자명
- 고광목,구자성,김영일,양재헌,Go. Kwang-Mook,Koo. Ja-Seong,Kim. Young-Il,Yang. Jae-Heon
- ㆍ 간행물명
- 藥劑學會誌
- ㆍ 권/호정보
- 1999년|29권 4호|pp.323-327 (5 pages)
- ㆍ 발행정보
- 한국약제학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
To protect ${eta}-carotene$ at the stomach and to release rapidly at the intestine we prepared alginate beads containing ${eta}-carotene$. ${eta}-carotene$ and alginate solution was homogenized and prepared o/w emulsion was prepared. It was poured into $Ca^{2+}$ solution through syringe needle. The gel was formed spontaneously and alginate beads containing ${eta}-carotene$ were prepared. ${eta}-Carotene$ was incorporated into the beads more than 95%. The release rate of ${eta}-carotene$ was dependent on the concentration of $Ca^{2+}$, ${eta}-carotene$ and surfactants. However, the concentration of alginate did not affect the release rate of ${eta}-carotene$. The high concentration of $Ca^{2+}$ slowed down the release rate of ${eta}-carotene$. The addition of surfactants in the ${eta}-carotene$beads increased the release rate of ${eta}-carotene$ in the order of Tween 80 > Cremophor > Span 20. The contents of ${eta}-carotene$ and diameter of ${eta}-carotene$ beads did not change significantly at $50^{circ}C$ for 20 days.