This experiment was done to investigate the effects of Ojajiwhangeumja(OJWEJ) to the symptoms of senility. To prove the effects of OJWEJ we injected scopolamine(1mg/kg) to the vein of rats. And we measured the blood cells(WBC, RBC, Platelet), constituents of serum(BUN, creatinin, glucose, uric acid), endurance of films of the red blood cell to erythrocyte hemolises, the activity of cholinesterase in serum, TBA and the activity of catalase, SOD in the purified microsome of brain tissue of rats. The results were as follows; 1. The number of white blood cells, platelet was increased significantly in the group treated by OJWEJ in comparison with control group. 2. The number of BUN, creatinin, glucose of serum decreased significantly in the OJWEJ treated group compared with control group. 3. The erythrocyte hemolises in red blood cells restrained significantly in the group treated by OJWEJ in comparison with control group. 4. The activity of cholinesterase in OJWEJ treated group increased significantly compared with control group. 5. The amounts of malondialdehyde of serum decreased significantly in the OJWEJ treated group in comparison with control group. 6. The catalase in the microsome of rat brain was activated significantly in the group treated by OJWEJ compared with control group. 7. The superoxide dismutase in the group treated by OJWEJ activated significantly in comparison with control group. According to this experiment it is suggested that OJWEJ accelerates the activity of colinesterase and restrains the creation of erythrocyte hemolises and accumulation of senile substance. But I look forward to see the further research to be made.