This study was to investigate the metal accumulation from SipJeonDaeBo-Decoction to rat blood of Sprague Dawley. 1. There were no significance in body weight, water dose feed ingestion quantity, liver, kidney, brain, bone weights between the control and the experimental groups. Under the experiment with drinking waters was no metal ${sim};0.65mg/L$ detected. Metal level within feed found 0.0001-376.983mg/kg. 2. In the pack of SipJeonDaeBo-decoction, there detected no metal ${sim}2.086mg/L$ 3. After P.O(per os) SipJeonDaeBo-decoction, As is detected $2.390{pm}0.812mg/kg$ in blood; Cd $0.001{pm}0.001mg/kg$, Co $0.003{pm}0.001mg/kg$, Cr $0.432{pm}0.234mg/kg$, Cu $1.013{pm}0.373mg/kg$, Fe $426.293{pm}114.842mg/kg$, no Hg, Mn $0.109{pm}0.082mg/kg$, Ni $0.122{pm}0.068mg/kg$, Zn $3.584{pm}1.270mg/kg$. 4. The concentration of Hazardous heavy metal (As, Cd, Co, Cr, Hg, Ni, Pb) within blood control group is searched $0.488{pm}0.138;mg/l$; experiment I group $0.432{pm}0.080mg/l$, experiment II group $0.588{pm}0.213mg/l$. In the concentration of non hazardous heavy metal(Cu, Fe, Mn, Zn) control group $101.409{pm}6.832mg/l$; experiment I group $96.062{pm}5.732;mg/l$, experiment II group $125.139{pm}044.820mg/l$. 5. Correlation among every metal in blood Zn and Cr was 0.87956 ; Cd and As -0.02316, Pb and As -0.08738, Ni and As 0.07824, Mn and As 0.07824, Mn and Cd 0.04999. Briefly under the injection of SipJeonDaeBo-decoction, this study was defined within safety in blood level by P.O. during 10 days.