This paper deals with the fault detection problem in uncertain linear multivariable systems and its application. A robust fault detection method presented by Kim et a. (1998) for MIMO (Multi Input/Multi Output) systems has been adopted and applied to the twin rotor MIMO experimental setup using industrial DSP. The system identification problem is formulated for the twin rotor MIMO system and its parameters are estimated using experimental data. Based on the estimated parameters, some fault detection simulations are performed using the robust fault detection method, which shows that the preformance is satisfied.