The auxiliary transformers or start-up/stand-by transformer(s) are installed against the start-up and shut-down of generator and emergency status in fossil power plant. The on-site power supply configuration using these transformers must be determined, considering configuration requirements, site characteristics, reliability and availability severely because it is remarkably important for safety and ecfonomy of plant. The auxiliary or start-up/stand-by power supply configuration has been determined considering only safety requirements and construction cost until now in Korea. This paper presents general theorems for the reliability estimation and proposes 2-unit based 4 alternatives for the start-up power supply stystem of 500㎿ standardized fossil power plant. The reliability and unavailability of equipment, system and configuration are determined using minimal cut-set methodology. The optimized plan of 4 alternatives is determined based on this ultimate reliability and unavailability.