In this paper, neural network predictive PID (NNPPID) control system is proposed to reduce the vibration of building structure. NNPPID control system is made up predictor, controller, and self-tuner to yield the parameters of controller. The neural networks predictor forecasts the future output based on present input and output of building structure. The controller is PID type whose parameters are yielded by neural networks self-tuning algorithm. Computer simulations show displacements of single and multi-story structure applied to NNPPID system about disturbance loads-wind forces and earthquakes.