This paper develops an real-time expert system for the electronic interlocking system. it obtains the higher safety by determining the railway interlocking strategy in order to prevent trains from colliding, and derailing in the viewpoint of veteran expert, considering the situation of station in real-time. The expert system determines the real-time interlocking strategy by confirming the interlocking relationships among signal facilities based on the interlocking knowledge base from input information such as signal, points, and it is implemented as the rule-based system in order to represented accurately and effectively the interlocking relationships. Especially in case of emergency the function which determines the rational route coordinating with IIKBAG on the workstation is designed in order to minimize the spreading effect. It is implemented in C computer language for the purpose of the implementation of the inference engine using the dynamic memory allocation technique, the build and interface of the station structure database. And, the validity of the built expert system is proved by simulating the diversity cases which may occur in the real system for the typical station model.