Monitoring of groundwater Quality is essential for the preservation of groundwater resources. In practice. however, groundwater monitoring network is designed based on the experience and intuition of experts or on the convenience. This study proposes a simulation-optimization approach for the optimal design of monitoring networks. In it, the predicted three-dimensional concentration data are used as the input of an optimization problem. Various design objectives and constraints are considered and the problem is formulatcu as the 0-1 integer programming. The methodology was applied to a sanitary landfill site. The results show that the monitoring network configuration changes as the monitoring goal, operation time and constraints vary. The proposed method turns out to be an efficient tool for the wide range of groundwater Quality monitoring network design problems.oblems.