A Periodic disturbance canceller is proposed to compensate for the periodic disturbance due to cutting process in a CNC machining center. The periodic disturbance canceller estimates the Periodic disturbance without phase delay. This is achieved by using linear phase low-pass filter and frequency response reciprocal filter of plant at the frequency of the periodic disturbance. This method is implemented in the position control system of the CNC machining center with general disturbance compensators in order to compensate for both the frictional force and the periodic disturbance. The experimental results are described to show its effectiveness.